- Robust efficacy results achieved in multiple sclerosis mouse model with record-breaking
- Vitae’s time from initiation of program to animal proof-of-principle with qualified lead has
consistently been less than 18 months
FORT WASHINGTON, PA – June 4, 2013 – Vitae Pharmaceuticals, Inc., a clinical-stage
biopharmaceutical company discovering and developing novel, small molecule, first- and bestin-class compounds, today announced that it has achieved animal proof-of-principle of one of its
ROR gamma t (RORγt) inhibitor candidates in an experimental allergic encephalitis (EAE)
mouse model of multiple sclerosis in only nine months, breaking the company’s previous record
of 12 months. Vitae is studying its RORγt inhibitors for the treatment of a wide range of
autoimmune disorders, including rheumatoid arthritis, psoriasis, steroid-resistant asthma and
In the study, VTP-xx1 significantly reduced the severity of disease at both 10 mg/kg and 30
mg/kg oral doses. The compound demonstrated decreases in multiple cytokines/cytokine
receptors in vivo, and a 50-70 percent decrease in mRNA levels of interleukin-17A (IL-17A),
interleukin-17F (IL-17F) and the receptor for interleukin-23 (IL-23R). The compound was well
tolerated at all doses.
“We are excited about these data as they show that Vitae’s discovery technology platform
generates compounds that are safe and efficacious in a highly relevant animal model,” said Jeff
Hatfield, CEO of Vitae. “Our RORγt program is a great example of Vitae’s ability to rapidly and
consistently innovate against difficult targets in high-impact therapeutic categories.”
Vitae’s structure-based drug discovery approach has consistently demonstrated superior speed
and performance. Time from program initiation to animal proof-of-principle with a qualified lead
has been less than 18 months in each of Vitae’s programs with hard-to-drug targets. The
company’s speed in its RORt program bests that of its LXR program for atherosclerosis, which
achieved animal proof-of-principle in 12 months.
RORt inhibits the production of IL-17, a pro-inflammatory cytokine that is a key contributor to
the pathogenesis of autoimmune inflammatory diseasessuch as psoriasis, rheumatoid arthritis,
multiple sclerosis and asthma. Focusing on a small molecule solution, in just six months Vitae
was able to design and synthesize compounds that solve the most critical discovery challenges
including potency, isotype selectivity and PK.
“We look forward to advancing this program, which has the potential to be a first-in-class and
best-in-class disease modifying agent for the treatment of autoimmune disease,” said Hatfield.
About Vitae Pharmaceuticals
Vitae Pharmaceuticals is a clinical-stage biopharmaceutical company discovering and
developing a portfolio of novel, small molecule, best-in-class compounds that address important
disease areas, including chronic kidney disease, diabetes, Alzheimer’s disease, and
inflammation / autoimmunity.
Vitae excels at structure-based drug discovery and combines a proprietary technical platform
with the insights of world class scientists to advance best-in-class compounds for high value,
hard-to-drug targets. The accuracy and speed of Vitae’s drug discovery platform has enabled
the company to discover and advance attractive compounds in multiple therapeutics areas in a
rapid and highly capital efficient manner.
For additional information, please visit the company’s website at www.vitaepharma.com.